Managing hemophilia can bring challenges
Are you facing challenges with your current factor treatment?
Are you still experiencing breakthrough bleeds despite using Factor 9 treatment?
Based on a survey over a 12-month period in a real-world study of 150 people with hemophilia B
people with hemophilia B using Factor 9 reported experiencing at least 1 bleeda
81% of 114 patients on standard half-life Factor 9 and 68% of 36 patients on extended half-life Factor 9 reported ≥1 bleed in the past year
Of the 150 patients, 33% received on-demand treatment and 67% received prophylaxis
aData from a study with 150 people in the United States and Europe who received Factor 9 treatment. Bleed data were patient reported from the previous 12 months. People in the United States had lower bleeding rates than those in Europe, which may affect how this information applies to different people. Findings have not been confirmed by a clinical study that compared treatments.
In a real-world study that included 112 people with hemophilia B
~1 in 4 of 65 people with hemophilia B on factor treatment said they felt worried about adequate protection from bleeds at least sometimesb
bData from an online survey through PicnicHealth from 2020-2022 among 112 people with hemophilia B in the United States. The survey used a cross-sectional study design to collect answers. A person’s answers could change over time, and the study didn’t track patients continuously. Survey response options were: “Never,” “Rarely,” “Sometimes,” “Often,” and “Always.” Findings have not been confirmed by a clinical study that compared treatments.
Do vein health or administration challenges cause you to delay or avoid treatment?
In a real-world study of people with hemophilia B
of 65 people reported feeling worried about losing access to a vein due to their current factor treatment at least sometimesb
of 65 people reported having physical discomfort due to treatment administration at least sometimesb
Nearly
of 65 people reported experiencing blown or ruptured veins due to their treatment at least sometimesb
bData from an online survey through PicnicHealth from 2020-2022 among 112 people with hemophilia B in the United States. The survey used a cross-sectional study design to collect answers. A person’s answers could change over time, and the study didn’t track patients continuously. Survey response options were: “Never,” “Rarely,” “Sometimes,” “Often,” and “Always.” Findings have not been confirmed by a clinical study that compared treatments.
Have you ever avoided activities due to factor level concerns?
Bleed protection can vary between doses, due to "peaks and troughs" in Factor 9 levels
Would you consider a therapy that provides a steady level of bleed protection without peaks and troughs?
You deserve daily bleed protection with a treatment
DESIGNED TO MEET THE CHALLENGES OF HEMOPHILIA B
Living with hemophilia B with inhibitors, you may face serious challenges and potential risks with limited treatment options.
Bleeds can lead to joint damage, so having preventative treatment is essential
In a real-world study of people with hemophilia, including hemophilia B with inhibitors:
Median Annual Bleed Rate
Bleeds per year
when using bypassing agents on demand
(16 people)a
Bleeds per year
when using bypassing agents as prophylaxis
(15 people)a
aThis study looked at past records of patients with hemophilia, including 31 male adults and adolescents aged 12 years and older who have hemophilia B with inhibitors, of any severity. It aimed to learn more about their everyday needs. In the study, 16 of them used bypassing agents only when a bleed happened (on demand), and on average, they used this treatment for about 9 years (111 months). The other 15 people used these treatments as a preventive prophylaxis, doing so for around 7 years (85 months) on average. The study also looked at how often bleeds happened each year (median bleeds per year).
Until now, your only option for bleed protection has left you vulnerable to
Severe allergic reactions
(anaphylaxis)
Numerous IV administration
steps including mixing
Multiple IV infusions per week for prophylaxis
IV=intravenous
You deserve daily bleed protection with a treatment made with your challenges in mind
For people living with hemophilia A with inhibitors, you deserve more options to protect against bleeds
Unpredictable bleeds persist
of patients (70 people) on nonfactor therapy that works like Factor 8 (Factor 8 mimetic) experienced at least 1 spontaneous bleed.
In a real-world observational study conducted by the Israeli National Hemophilia Center that observed the breakthrough bleeding patterns were analyzed in patients with severe hemophilia A, with or without inhibitors, receiving prophylactic Factor 8 mimetic therapy and completing ≥18 months of follow-up (n=28 patients with hemophilia A with inhibitors). Results include people who have hemophilia A with or without inhibitors (42 patients without inhibitors). Findings have not been confirmed by a clinical or randomized controlled trial.
of patients on bypassing agent prophylaxis experienced at least 1 spontaneous bleed.
In a study conducted in Europe that observed real-world use of aPCC for patients with hemophilia A with inhibitors or hemophilia B with inhibitors, receiving aPCC treatment on demand or prophylactically for more than 4 years in routine clinical practice (n=36 patients with hemophilia A with inhibitors and 1 patient with hemophilia B with inhibitors received aPCC prophylaxis). Findings have not been confirmed by a clinical or randomized control trial.
aPCC=activated prothrombin complex concentrate.
TALK TO YOUR DOCTOR about a solution that helps address your needs and supports you in achieving your goals.
Heavy treatment burden adds to the challenge
Time-consuming administration
Nonfactor therapy can take up to 15 minutes to prepare and inject with vials and syringes.
Pain and discomfort
May include using large, thick needles (23G-27G) for injections.
Complicated administration
Multiple steps and supplies to prepare and administer treatment.
You should expect your treatment to work the way you need it to
